ARIA
Library/skin aesthetic/GHK-Cu

GHK-Cu

Not FDA Approved✓ WADA Permitted

Copper Peptide / GHK-Copper Complex

skin aesthetic◈Clinical EvidenceCopper-binding tripeptide

Human plasma tripeptide (Gly-His-Lys) bound to copper 2+. Declines with age. Stimulates collagen, tightens skin, reduces wrinkles/fine lines, promotes wound healing. Topical and injectable forms.

Confidence
82%
Half-Life ~hours
Cost ~$60/mo
Quick Reference
Routetopical
MechanismCopper delivery to fibroblasts → collagen I/III/GAG synthesis. Modulates MMPs/TI...
SequenceGHK-Cu
Mol. Weight403.9 Da
Reviewed2026-07-08

Mechanism of Action

Copper delivery to fibroblasts → collagen I/III/GAG synthesis. Modulates MMPs/TIMPs. Attracts immune and endothelial cells. Up/downregulates ~4,000 genes. Anti-inflammatory, skin remodeling. Activates decorin and heparan sulfate.

Dosing Protocol

Topical: 100-500ppm in serum/cream, applied BID to face or incision sites. Microneedling enhances absorption.

Key Studies

2015

GHK as Natural Modulator of Skin Regeneration

PMID 26236730review
2026

Injectable peptide therapy primer

PMID 41476424narrative_review

Adverse Effects

Generally well toleratedRare skin irritationCopper sensitivity (rare)

Contraindications

  • Copper metabolism disorders (Wilson's disease)

Storage

Room temperature. Protect from light. Stable in most cosmetic formulations.

Clinical Applications

  • ["skin_quality"
  • "post_surgical_healing"
  • "anti_aging"
  • "wrinkle_reduction"]