ARIA
Library/regeneration/TB-500

TB-500

Not FDA Approved⛔ WADA Banned

Thymosin Beta-500 / Synthetic Thymosin β4 fragment

regeneration◆EmergingThymosin beta-4 analog

Synthetic thymosin β4 fragment. Promotes angiogenesis, tissue repair, cell migration, reduces fibrosis. WADA banned. Popular in sports/bodybuilding.

Confidence
45%
Half-Life ~hours (rapid tissue uptake)
Cost ~$400/mo
Quick Reference
Routesubcutaneous
MechanismBinds G-actin → actin polymerization → cell migration. VEGF and laminin-5 upregu...
SequenceSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Mol. Weight4921.3 Da
Reviewed2026-07-08

Mechanism of Action

Binds G-actin → actin polymerization → cell migration. VEGF and laminin-5 upregulation. Anti-inflammatory. Anti-apoptotic in cardiac/neural cells.

Dosing Protocol

2-5mg SC 2x/wk x4-6wks (loading), then 1-2mg 1-2x/wk (maintenance).

Key Studies

2024

TB-500 quantification and wound healing

PMID 38382158preclinical
2026

Injectable peptide therapy primer

PMID 41476424narrative_review

Adverse Effects

Limited human safety dataInjection site painFatigueHeadacheTheoretical tumor promotion (angiogenesis)

Contraindications

  • Active malignancy
  • Pregnancy
  • Competitive athletes

Storage

Lyophilized: room temp or frozen. Reconstituted: refrigerate 2-8°C, use within 2 weeks.

Clinical Applications

  • ["post_surgical_recovery"
  • "tissue_repair"
  • "wound_healing"]