ARIA
Library/hormonal/Tesamorelin

Tesamorelin

FDA Approved✓ WADA Permitted

Egrifta SV

hormonalFDA ApprovedGHRH analog

FDA-approved GHRH analog for HIV-associated lipodystrophy. Stimulates endogenous GH, reduces visceral adipose tissue ~15%. Off-label aesthetic body contouring potential.

Confidence
88%
Half-Life ~26 minutes
Cost ~$3500/mo
Quick Reference
Routesubcutaneous
MechanismMimics GHRH at pituitary somatotroph receptors → increased GH synthesis and secr...
SequenceYFTSSYSRFSDKHLDVLKQ
Mol. Weight5134.9 Da
Reviewed2026-07-08

Mechanism of Action

Mimics GHRH at pituitary somatotroph receptors → increased GH synthesis and secretion → elevated IGF-1 → enhanced lipolysis, reduced visceral adiposity.

Dosing Protocol

2mg SC daily (FDA label). Off-label similar dosing for visceral fat reduction.

Key Studies

2007

Tesamorelin reduces VAT in HIV lipodystrophy

PMID 17574417rct
2026

Tesamorelin vs GLP-1 in visceral fat

PMID 42139091case_series

Adverse Effects

Injection site reactionsPeripheral edemaCarpal tunnelHyperglycemiaArthralgiaMyalgia

Contraindications

  • Active malignancy
  • Pregnancy
  • Hypothalamic-pituitary disruption

Storage

Refrigerate at 2-8°C. Reconstitute with provided diluent. Use within 24 hours of reconstitution.

Clinical Applications

  • ["visceral_fat_reduction"
  • "body_contouring_adjunct"
  • "hiv_lipodystrophy"]